Precision diagnosis and treatment of gastric precancerous lesions based on space-time view
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摘要: 胃癌前病变(GPL)是一类容易进展为胃癌的黏膜病理组织学病变,目前尚无公认有效的治疗方案推荐。中医治疗本病具有独特优势,能够改善症状、逆转病变和延缓疾病进展。中国精准医疗计划于2016年启动,近年愈来愈多提倡中医药精准医疗。时昭红教授提出基于时空观的GPL精准辨治模式,在时间维度上,将疾病发展阶段证候特点从虚实两端精准分期而治;依据“四时五脏阴阳”不同精准用药,同时预见性辨证用药,精准防止疾病进展。在空间维度上,结合地域环境、体质个体化施治,并结合内镜技术与病理从内部与微观层面精准辨证论治,延伸了中医望诊与辨证的内涵,为GPL临床辨治提供了更加动态而全面的参考。Abstract: Gastric precancerous lesions(GPL) are a category of mucosal histopathological changes that can progress to gastric cancer. Currently, there is no universally accepted effective treatment recommendation for GPL. Traditional Chinese medicine(TCM) offers distinct advantages in treating this condition, including symptom improvement, lesion reversal, and slowing disease progression. The China Precision Medicine Initiative, launched in 2016, has increasingly emphasized TCM-based precision medicine in recent years. Professor Shi Zhaohong has proposed a precise diagnosis and treatment model for GPL based on a space-time view. In the temporal dimension of disease development, treatments are precisely differentiated for deficiency stage and excess stage. Based on the principles of "The Interplay of the Five Zang Organs and Yin-Yang Throughout the Four Seasons", precise herbal medicine is offered, along with anticipatory individualized treatment to prevent disease progression. In the spatial dimension, personalized treatment is realized by combining regional environmental factors and physique constitution, and endoscopic techniques and pathology are used for precise diagnosis and treatment at the internal and microscopic levels. This approach extends the scope of TCM inspection technique and syndrome differentiation, offering a more dynamic and comprehensive reference for the clinical management of GPL.
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[1] 国家消化系疾病临床医学研究中心(上海), 国家消化道早癌防治中心联盟, 中华医学会消化病学分会幽门螺杆菌学组, 等. 中国胃黏膜癌前状态和癌前病变的处理策略专家共识(2020年)[J]. 中华消化杂志, 2020, 40(11): 731-741.
[2] 中华医学会消化病学分会. 中国慢性胃炎共识意见(2017年, 上海)[J]. 胃肠病学, 2017, 22(11): 670-687. https://xuewen.cnki.net/CCND-WEHU202407070012.html
[3] 何友成, 骆云丰, 杨正宁, 等. 国医大师杨春波辨治慢性萎缩性胃炎的经验[J]. 湖南中医药大学学报, 2021, 41(7): 977-981. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX202107001.htm
[4] 安静, 彭继升, 魏玥, 等. 胃癌前病变的辨治思路[J]. 中华中医药杂志, 2020, 35(11): 5626-5629. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202011076.htm
[5] 李昆阳, 刘华一, 仝菲. 从"因滞致虚, 因虚夹邪"论治慢性萎缩性胃炎癌前病变[J]. 天津中医药, 2021, 38(5): 604-607. https://www.cnki.com.cn/Article/CJFDTOTAL-TJZY202105017.htm
[6] 沈洪. 慢性萎缩性胃炎及其癌前病变治疗之管见[J]. 江苏中医药, 2007, 39(8): 6-7. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY200708006.htm
[7] 王萍, 李鹏, 陈萦晅, 等. 中国整合胃癌前病变临床管理指南[J]. 中国中西医结合消化杂志, 2022, 30(3): 163-183. https://zxyxh.whuhzzs.com/article/doi/10.3969/j.issn.1671-038X.2022.03.01
[8] 梁健, 周凤蕊, 邓鑫, 等. 时空医学在中医学中的应用[J]. 中医研究, 2010, 23(11): 3-4. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYJ201011004.htm
[9] 周曼丽, 简维雄. 基于中医时空医学理论探讨冠心病血瘀证的形成机制[J]. 实用心脑肺血管病杂志, 2023, 31(1): 91-95. https://www.cnki.com.cn/Article/CJFDTOTAL-SYXL202301016.htm
[10] 郭蕾, 王永炎, 张志斌. 关于证候概念的诠释[J]. 北京中医药大学学报, 2003, 26(2): 5-8. https://www.cnki.com.cn/Article/CJFDTOTAL-JZYB200302001.htm
[11] 胡力丹, 钱袁媛, 揭晓, 等. 基于中医时空医学探讨瘀、毒、郁所致动脉粥样硬化性心血管疾病[J]. 中医杂志, 2022, 63(7): 624-627. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202207005.htm
[12] 李杰, 朱广辉. 五观辨治-构建中医药防治肿瘤新体系[J]. 中国实验方剂学杂志, 2022, 28(13): 225-232. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202213028.htm
[13] 陈健, 陈启龙, 苏式兵. 中医药精准医疗的思考与探索[J]. 世界科学技术-中医药现代化, 2016, 18(4): 557-562. https://www.cnki.com.cn/Article/CJFDTOTAL-SJKX201604003.htm
[14] 庞博, 姜晓晨, 朴炳奎, 等. 肿瘤辨病论治临床思维方法探讨[J]. 北京中医药, 2020, 39(5): 397-401. https://www.cnki.com.cn/Article/CJFDTOTAL-BJZO202005001.htm
[15] 张学智, 魏玮, 蓝宇. 成人幽门螺杆菌引起的胃炎中西医协作诊疗专家共识(2020, 北京)[J]. 中医杂志, 2020, 61(22): 2016-2024. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202022023.htm
[16] 刘又前, 沈洪. 沈洪教授治疗慢性萎缩性胃炎癌前病变经验[J]. 中医药导报, 2019, 25(3): 97-98, 106. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB201903029.htm
[17] 陈曦, 李丹玉, 莫雅婷, 等. 探析《内外伤辨惑论》中蕴含的五运六气思想[J]. 中国中医基础医学杂志, 2023, 29(2): 210-211, 215. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202302008.htm
[18] 赵倩文, 石芳, 许静茹, 等. 刘启泉基于四时用药理论论治慢性萎缩性胃炎[J]. 时珍国医国药, 2022, 33(4): 979-980. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202204061.htm
[19] 吴昕妍, 张慧, 凌燕雯, 等. 基于治未病思想探讨胃癌前病变的防治[J]. 世界中西医结合杂志, 2022, 17(10): 2106-2109. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202210036.htm
[20] 陈泽慧, 杨晋翔, 韩海啸, 等. 慢性萎缩性胃炎患者出生季节与体质类型分布规律的相关性分析[J]. 中华中医药杂志, 2018, 33(1): 359-361. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201801097.htm
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